Abstract Background Oral methotrexate (MTX) is the first-line therapy for patients with rheumatoid arthritis (RA).However, approximately one quarter of patients discontinue MTX within 12 months.MTX failure, defined as MTX cessation or the addition of another anti-rheumatic drug, is usually due adverse event(s) and/or inefficacy.The aims of this stu
Abstract Small open reading frames (smORFs) shorter than 100 codons are 639 widespread and perform essential roles in microorganisms, where they encode proteins active in several cell functions, including signal pathways, stress response, and antibacterial activities.However, the ecology, distribution and role of small proteins in the global microb
Vertebrate tracks are subject to a wide distribution of morphological types.A single trackmaker may be associated with a range of tracks reflecting individual pedal anatomy and behavioural kinematics mediated through substrate properties which may vary both in space and time.Accordingly, the same trackmaker can leave substantially different morphot
While Blockchain technology is universally considered as a significant technology for the near future, some of its pillars are Gift Wrap under a threat of another thriving technology, Quantum Computing.In this paper, we propose important safeguard measures against this threat by developing a framework of a quantum-secured, permissioned blockchain c